O-20: Maternal Age and Congenital Malformation in Yazd, Islamic Republic of Iran

Background: Congenital malformation (CM) is the major health problems in childhood because treatment and rehabilitation of children with CM is costly and complete recovery is usually impossible. For most of single primary defect the etiology is unknown. The aim of this study was to determine frequency of CM and its association with maternal age. Materials and Methods: This descriptive-observational study carried on 4800 births delivered at all maternity hospitals. The type of birth defects was classified by the diagnostic standardization of congenital malformation from the International classification of diseases (ICD-10) codes. Data were analyzed by SPSS version 17. The level of significance was p<0.05. Results: In this study the prevalence of CM was 2.83%. Musculoskeletal anomaly, central nervous system and genital system were accounted as the most common. Overall the mean maternal age in group with CM and normal newborns was 25 ± 2.75 years and 22 ± 3.23 years, respectively (p=0.43) .There was not statistically significant difference between prevalence of CM and mother&#039;s age. Conclusion: Prevalence of congenital malformation among the newborn was higher than previous reported from Iran and we noticed that, there is not an association between maternal age and increase risk of CM.